Structure-Based Design of Novel Dihydroalkoxybenzyloxopyrimidine Derivatives as Potent Nonnucleoside Inhibitors of the Human Immunodeficiency Virus Reverse Transcriptase

Two highly potent dihydroalkoxybenzyloxopyrimidine (DABO) derivatives targeting the nonnucleoside inhibitor (NNI) binding site of human immunodeficiency virus (HIV) reverse transcriptase (RT) have been designed based on the structure of the NNI binding pocket and tested for anti-HIV activity. Our le...

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Εκδόθηκε σε:	Antimicrob Agents Chemother
Κύριοι συγγραφείς:	Sudbeck, Elise A., Mao, Chen, Vig, Rakesh, Venkatachalam, T. K., Tuel-Ahlgren, Lisa, Uckun, Fatih M.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 1998
Θέματα:	Antiviral Agents
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC106026/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9835518/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.12.3225
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