Coresistance to Zidovudine and Foscarnet Is Associated with Multiple Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Human immunodeficiency virus type 1 (HIV-1) isolates obtained from a patient with AIDS were assessed for coresistance to foscarnet and zidovudine. An HIV-1 strain (AP20) coresistant to foscarnet and zidovudine was isolated after 20 months of continuous combination therapy. The reverse transcriptase...

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Bibliographic Details
Main Authors: Tachedjian, Gilda, French, Martyn, Mills, John
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC105992/
https://ncbi.nlm.nih.gov/pubmed/9797252
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