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The L74V Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Counteracts Enhanced Excision of Zidovudine Monophosphate Associated with Thymidine Analog Resistance Mutations

Thymidine analog mutations (TAMs) in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) confer resistance to zidovudine (AZT) by increasing the rate of ATP-dependent phosphorolysis of the terminal nucleotide monophosphate (primer unblocking). By contrast, the L74V mutation, which...

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書誌詳細
主要な著者: Miranda, Luis R., Götte, Matthias, Kuritzkes, Daniel R.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168711/
https://ncbi.nlm.nih.gov/pubmed/15980332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.7.2648-2656.2005
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