Targeted elimination of zygotic messages in Xenopus laevis embryos by modified oligonucleotides possessing terminal cationic linkages

We have designed a new class of modified antisense oligodeoxyribonucleotides (ODN) consisting of a central contiguous stretch of 6–8 unmodified nucleotides flanked by 3′- and 5′-regions containing several nucleotides joined by cationic internucleoside linkages. The positive charge results from modif...

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Main Authors: Dagle, John M., Littig, Jennifer L., Sutherland, Lillian B., Weeks, Daniel L.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2000
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC105372/
https://ncbi.nlm.nih.gov/pubmed/10773085
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