Positively charged oligonucleotides overcome potassium-mediated inhibition of triplex DNA formation.

The formation of triplex DNA using unmodified, purine-rich oligonucleotides (ODNs) is inhibited by physiologic levels of potassium. Changing negative phosphodiester bonds in a triplex forming oligonucleotide (TFO) to neutral linkages causes a small increase in triplex formation. When phosphodiester...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Dagle, J M, Weeks, D L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145908/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8668547/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.11.2143
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