Positively charged oligonucleotides overcome potassium-mediated inhibition of triplex DNA formation.
The formation of triplex DNA using unmodified, purine-rich oligonucleotides (ODNs) is inhibited by physiologic levels of potassium. Changing negative phosphodiester bonds in a triplex forming oligonucleotide (TFO) to neutral linkages causes a small increase in triplex formation. When phosphodiester...
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| Vydáno v: | Nucleic Acids Res |
|---|---|
| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
1996
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145908/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8668547/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.11.2143 |
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