Targeted elimination of zygotic messages in Xenopus laevis embryos by modified oligonucleotides possessing terminal cationic linkages

We have designed a new class of modified antisense oligodeoxyribonucleotides (ODN) consisting of a central contiguous stretch of 6–8 unmodified nucleotides flanked by 3′- and 5′-regions containing several nucleotides joined by cationic internucleoside linkages. The positive charge results from modif...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Dagle, John M., Littig, Jennifer L., Sutherland, Lillian B., Weeks, Daniel L.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2000
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105372/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10773085/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.10.2153
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