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Characterization of the human and mouse WRN 3′→5′ exonuclease

Werner’s syndrome (WS) is an autosomal recessive disorder in humans characterized by the premature development of a partial array of age-associated pathologies. WRN, the gene defective in WS, encodes a 1432 amino acid protein (hWRN) with intrinsic 3′→5′ DNA helicase activity. We recently showed that...

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Detalhes bibliográficos
Main Authors: Huang, Shurong, Beresten, Sergey, Li, Baomin, Oshima, Junko, Ellis, Nathan A., Campisi, Judith
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC102739/
https://ncbi.nlm.nih.gov/pubmed/10871373
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