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Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity
The premature human aging Werner syndrome (WS) is caused by mutation of the RecQ-family WRN helicase, which is unique in possessing also 3′–5′ exonuclease activity. WS patients show significant genomic instability with elevated cancer incidence. WRN is implicated in restraining illegitimate recombin...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2408639/ https://ncbi.nlm.nih.gov/pubmed/18346216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2008.00388.x |
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