Formaldehyde activation of mitoxantrone yields CpG and CpA specific DNA adducts

Recently we have found that mitoxantrone, like Adriamycin, can be activated by formaldehyde and subsequently form adducts which stabilise double-stranded DNA in vitro. This activation by formaldehyde may be biologically relevant since formaldehyde levels are elevated in those tumours in which mitoxa...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Parker, Belinda S., Cutts, Suzanne M., Cullinane, Carleen, Phillips, Don R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10648792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.4.982
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