Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct.

MAR70 is a synthetic derivative of the anticancer drug daunorubicin that contains an additional sugar, attached to the O4' of daunosamine. When MAR70 was crystallized with the DNA hexamer d(CGTnACG), where nA is 2-aminoadenine, a covalent methylene bridge was formed between the N3' of daun...

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Hauptverfasser: Gao, Y G, Liaw, Y C, Li, Y K, van der Marel, G A, van Boom, J H, Wang, A H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1991
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC51763/
https://ncbi.nlm.nih.gov/pubmed/2052564
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