Formaldehyde activation of mitoxantrone yields CpG and CpA specific DNA adducts

Recently we have found that mitoxantrone, like Adriamycin, can be activated by formaldehyde and subsequently form adducts which stabilise double-stranded DNA in vitro. This activation by formaldehyde may be biologically relevant since formaldehyde levels are elevated in those tumours in which mitoxa...

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Vydáno v:	Nucleic Acids Res
Hlavní autoři:	Parker, Belinda S., Cutts, Suzanne M., Cullinane, Carleen, Phillips, Don R.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 2000
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10648792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.4.982
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