Formaldehyde activation of mitoxantrone yields CpG and CpA specific DNA adducts

Recently we have found that mitoxantrone, like Adriamycin, can be activated by formaldehyde and subsequently form adducts which stabilise double-stranded DNA in vitro. This activation by formaldehyde may be biologically relevant since formaldehyde levels are elevated in those tumours in which mitoxa...

Полное описание

Библиографические подробности

Опубликовано в::	Nucleic Acids Res
Главные авторы:	Parker, Belinda S., Cutts, Suzanne M., Cullinane, Carleen, Phillips, Don R.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Oxford University Press 2000
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10648792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.4.982
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