Formaldehyde activation of mitoxantrone yields CpG and CpA specific DNA adducts

Recently we have found that mitoxantrone, like Adriamycin, can be activated by formaldehyde and subsequently form adducts which stabilise double-stranded DNA in vitro. This activation by formaldehyde may be biologically relevant since formaldehyde levels are elevated in those tumours in which mitoxa...

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書目詳細資料

發表在:	Nucleic Acids Res
Principais autores:	Parker, Belinda S., Cutts, Suzanne M., Cullinane, Carleen, Phillips, Don R.
格式:	Artigo
語言:	Inglês
出版:	Oxford University Press 2000
主題:	Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10648792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.4.982
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