Genomic Targeting of Methylated DNA: Influence of Methylation on Transcription, Replication, Chromatin Structure, and Histone Acetylation

We have developed a strategy to introduce in vitro-methylated DNA into defined chromosomal locations. Using this system, we examined the effects of methylation on transcription, chromatin structure, histone acetylation, and replication timing by targeting methylated and unmethylated constructs to ma...

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Главные авторы: Schübeler, Dirk, Lorincz, Matthew C., Cimbora, Daniel M., Telling, Agnes, Feng, Yong-Quing, Bouhassira, Eric E., Groudine, Mark
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2000
Предметы:
Gene Expression
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC102168/
https://ncbi.nlm.nih.gov/pubmed/11094062
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