DNA Methylation Density Influences the Stability of an Epigenetic Imprint and Dnmt3a/b-Independent De Novo Methylation

DNA methylation plays an important role in transcriptional repression. To gain insight into the dynamics of demethylation and de novo methylation, we introduced a proviral reporter, premethylated at different densities, into a defined chromosomal site in murine erythroleukemia cells and monitored th...

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Autori principali: Lorincz, Matthew C., Schübeler, Dirk, Hutchinson, Shauna R., Dickerson, David R., Groudine, Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Transcriptional Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC135678/
https://ncbi.nlm.nih.gov/pubmed/12370304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.21.7572-7580.2002
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