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Methylation-dependent silencing at the H19 imprinting control region by MeCP2

Methylation of CpG dinucleotides is correlated with transcriptional repression of genes, including imprinted genes. In the case of the imprinted H19 gene, a 2 kb imprinting control region (ICR) is subject to differential methylation, as it is methylated only on the silenced paternal allele. This reg...

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Bibliographic Details
Main Authors: Drewell, Robert A., Goddard, Carolyn J., Thomas, Jean O., Surani, M. Azim
Format: Artigo
Language:Inglês
Published: Oxford University Press 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC101245/
https://ncbi.nlm.nih.gov/pubmed/11861904
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