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Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding

The activity of microsomal cytochromes P450 (CYP) is strictly dependent on the supply of electrons provided by NADPH cytochrome P450 oxidoreductase (CPR). The variant nature of the isoform-specific proximal interface of microsomal CYPs implies that the interacting interface between the two proteins...

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Autors principals: Francisco Esteves, Philippe Urban, José Rueff, Gilles Truan, Michel Kranendonk
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2020-09-01
Col·lecció:International Journal of Molecular Sciences
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Accés en línia:https://www.mdpi.com/1422-0067/21/18/6669
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