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Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica.

Autoantibodies that target the water channel aquaporin-4 (AQP4) in neuromyelitis optica (NMO) are IgG1, a T cell-dependent Ig subclass. However, a role for AQP4-specific T cells in this CNS inflammatory disease is not known. To evaluate their potential role in CNS autoimmunity, we have identified an...

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Detalhes bibliográficos
Main Authors: Patricia A Nelson, Mojgan Khodadoust, Thomas Prodhomme, Collin Spencer, Juan Carlos Patarroyo, Michel Varrin-Doyer, Joseph D Ho, Robert M Stroud, Scott S Zamvil
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2010-11-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC2994828?pdf=render
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