Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4

Aquaporin-4 (AQP4)-specific T cells are expanded in neuromyelitis optica (NMO) patients and exhibit Th17 polarization. However, their pathogenic role in CNS autoimmune inflammatory disease is unclear. Although multiple AQP4 T-cell epitopes have been identified in WT C57BL/6 mice, we observed that ne...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Sagan, Sharon A., Winger, Ryan C., Cruz-Herranz, Andrés, Nelson, Patricia A., Hagberg, Sarah, Miller, Corey N., Spencer, Collin M., Ho, Peggy P., Bennett, Jeffrey L., Levy, Michael, Levin, Marc H., Verkman, Alan S., Steinman, Lawrence, Green, Ari J., Anderson, Mark S., Sobel, Raymond A., Zamvil, Scott S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2016
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187685/
https://ncbi.nlm.nih.gov/pubmed/27940915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617859114
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