Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4

Aquaporin-4 (AQP4)-specific T cells are expanded in neuromyelitis optica (NMO) patients and exhibit Th17 polarization. However, their pathogenic role in CNS autoimmune inflammatory disease is unclear. Although multiple AQP4 T-cell epitopes have been identified in WT C57BL/6 mice, we observed that ne...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sagan, Sharon A., Winger, Ryan C., Cruz-Herranz, Andrés, Nelson, Patricia A., Hagberg, Sarah, Miller, Corey N., Spencer, Collin M., Ho, Peggy P., Bennett, Jeffrey L., Levy, Michael, Levin, Marc H., Verkman, Alan S., Steinman, Lawrence, Green, Ari J., Anderson, Mark S., Sobel, Raymond A., Zamvil, Scott S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187685/
https://ncbi.nlm.nih.gov/pubmed/27940915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617859114
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