Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4

Aquaporin-4 (AQP4)-specific T cells are expanded in neuromyelitis optica (NMO) patients and exhibit Th17 polarization. However, their pathogenic role in CNS autoimmune inflammatory disease is unclear. Although multiple AQP4 T-cell epitopes have been identified in WT C57BL/6 mice, we observed that ne...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Sagan, Sharon A., Winger, Ryan C., Cruz-Herranz, Andrés, Nelson, Patricia A., Hagberg, Sarah, Miller, Corey N., Spencer, Collin M., Ho, Peggy P., Bennett, Jeffrey L., Levy, Michael, Levin, Marc H., Verkman, Alan S., Steinman, Lawrence, Green, Ari J., Anderson, Mark S., Sobel, Raymond A., Zamvil, Scott S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187685/
https://ncbi.nlm.nih.gov/pubmed/27940915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617859114
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