Immunodominant T Cell Determinants of Aquaporin-4, the Autoantigen Associated with Neuromyelitis Optica

Autoantibodies that target the water channel aquaporin-4 (AQP4) in neuromyelitis optica (NMO) are IgG1, a T cell-dependent Ig subclass. However, a role for AQP4-specific T cells in this CNS inflammatory disease is not known. To evaluate their potential role in CNS autoimmunity, we have identified an...

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Detalhes bibliográficos
Main Authors: Nelson, Patricia A., Khodadoust, Mojgan, Prodhomme, Thomas, Spencer, Collin, Patarroyo, Juan Carlos, Varrin-Doyer, Michel, Ho, Joseph D., Stroud, Robert M., Zamvil, Scott S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994828/
https://ncbi.nlm.nih.gov/pubmed/21151500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015050
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