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Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica.
Autoantibodies that target the water channel aquaporin-4 (AQP4) in neuromyelitis optica (NMO) are IgG1, a T cell-dependent Ig subclass. However, a role for AQP4-specific T cells in this CNS inflammatory disease is not known. To evaluate their potential role in CNS autoimmunity, we have identified an...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science (PLoS)
2010-11-01
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Colecção: | PLoS ONE |
Acesso em linha: | http://europepmc.org/articles/PMC2994828?pdf=render |
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