<i>N</i>-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells

The main mechanistic function of most chemotherapeutic drugs is mediated by inducing mitochondria-dependent apoptosis. Tumor cells usually respond to upregulate autophagy to eliminate impaired mitochondria for survival. Hypothetically, inhibiting autophagy might promote mitochondria-dependent apopto...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Kun Wang, Bonan Chen, Ting Yin, Yujuan Zhan, Yuhua Lu, Yilin Zhang, Jiawei Chen, Weijie Wu, Shikun Zhou, Wenli Mao, Yuhui Tan, Biaoyan Du, Xiaodong Liu, Hiuting Idy HO, Jianyong Xiao
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: MDPI AG 2019-07-01
श्रृंखला:International Journal of Molecular Sciences
विषय:
<i>N</i>-Methylparoxetine
NSCLC
autophagy inhibition
ROS
MAPK
apoptosis
ऑनलाइन पहुंच:https://www.mdpi.com/1422-0067/20/14/3415
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