N-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells

The main mechanistic function of most chemotherapeutic drugs is mediated by inducing mitochondria-dependent apoptosis. Tumor cells usually respond to upregulate autophagy to eliminate impaired mitochondria for survival. Hypothetically, inhibiting autophagy might promote mitochondria-dependent apopto...

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Udgivet i:Int J Mol Sci
Main Authors: Wang, Kun, Chen, Bonan, Yin, Ting, Zhan, Yujuan, Lu, Yuhua, Zhang, Yilin, Chen, Jiawei, Wu, Weijie, Zhou, Shikun, Mao, Wenli, Tan, Yuhui, Du, Biaoyan, Liu, Xiaodong, HO, Hiuting Idy, Xiao, Jianyong
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6678301/
https://ncbi.nlm.nih.gov/pubmed/31336784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20143415
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