Blockage of Autophagic Flux and Induction of Mitochondria Fragmentation by Paroxetine Hydrochloride in Lung Cancer Cells Promotes Apoptosis via the ROS-MAPK Pathway

Cancer cells are characterized by malignant proliferation and aberrant metabolism and are thereby liable to the depletion of nutrients and accumulation of metabolic waste. To maintain cellular homeostasis, cancer cells are prone to upregulating the canonical autophagy pathway. Here, we identified pa...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Wang, Kun, Gong, Qing, Zhan, Yujuan, Chen, Bonan, Yin, Ting, Lu, Yuhua, Zhang, Yilin, Wang, Huiqi, Ke, Junzi, Du, Biaoyan, Liu, Xiaodong, Xiao, Jianyong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987457/
https://ncbi.nlm.nih.gov/pubmed/32039209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00397
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