<i>N</i>-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells

The main mechanistic function of most chemotherapeutic drugs is mediated by inducing mitochondria-dependent apoptosis. Tumor cells usually respond to upregulate autophagy to eliminate impaired mitochondria for survival. Hypothetically, inhibiting autophagy might promote mitochondria-dependent apopto...

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Hlavní autoři: Kun Wang, Bonan Chen, Ting Yin, Yujuan Zhan, Yuhua Lu, Yilin Zhang, Jiawei Chen, Weijie Wu, Shikun Zhou, Wenli Mao, Yuhui Tan, Biaoyan Du, Xiaodong Liu, Hiuting Idy HO, Jianyong Xiao
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2019-07-01
Edice:International Journal of Molecular Sciences
Témata:
<i>N</i>-Methylparoxetine
NSCLC
autophagy inhibition
ROS
MAPK
apoptosis
On-line přístup:https://www.mdpi.com/1422-0067/20/14/3415
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