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USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation

The H3K9me3 repressive histone conformation of p53 target promoters is abrogated in response to p53 activation by MDM2-mediated SUV39H1 degradation. Here, we present evidence that the USP7 deubiquitinase protects SUV39H1 from MDM2-mediated ubiquitination in the absence of p53 stimulus. USP7 occupies...

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Bibliografische gegevens
Hoofdauteurs: Sathish Kumar Mungamuri, Rui F. Qiao, Shen Yao, James J. Manfredi, Wei Gu, Stuart A. Aaronson
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2016-03-01
Reeks:Cell Reports
Onderwerpen:
p53
Online toegang:http://www.sciencedirect.com/science/article/pii/S221112471630170X
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