USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation

The H3K9me3 repressive histone conformation of p53 target promoters is abrogated in response to p53 activation by MDM2-mediated SUV39H1 degradation. Here, we present evidence that the USP7 deubiquitinase protects SUV39H1 from MDM2-mediated ubiquitination in the absence of p53 stimulus. USP7 occupies...

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Bibliographic Details
Main Authors: Sathish Kumar Mungamuri, Rui F. Qiao, Shen Yao, James J. Manfredi, Wei Gu, Stuart A. Aaronson
Format: Artigo
Language:Inglês
Published: Elsevier 2016-03-01
Series:Cell Reports
Subjects:
USP7
SUV39H1
H3K9me3
p53
MDM2
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471630170X
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