HITS-CLIP and Integrative Modeling Define the Rbfox Splicing-Regulatory Network Linked to Brain Development and Autism

The RNA binding proteins Rbfox1/2/3 regulate alternative splicing in the nervous system, and disruption of Rbfox1 has been implicated in autism. However, comprehensive identification of functional Rbfox targets has been challenging. Here, we perform HITS-CLIP for all three Rbfox family members in or...

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Hauptverfasser: Sebastien M. Weyn-Vanhentenryck, Aldo Mele, Qinghong Yan, Shuying Sun, Natalie Farny, Zuo Zhang, Chenghai Xue, Margaret Herre, Pamela A. Silver, Michael Q. Zhang, Adrian R. Krainer, Robert B. Darnell, Chaolin Zhang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014-03-01
Schriftenreihe:Cell Reports
Online Zugang:http://www.sciencedirect.com/science/article/pii/S2211124714000849
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