Role of Helicity on the Anticancer Mechanism of Action of Cationic-Helical Peptides

In the present study, the 26-residue amphipathic α-helical peptide A12L/A20L (Ac-KWKSFLKTFKSLKKTVLHTLLKAISS-amide) with strong anticancer activity and specificity was used as the framework to study the effects of helicity of α-helical anticancer peptides on biological activities. Helicity was system...

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Bibliografische gegevens
Hoofdauteurs: Yu-Xin Chen, Hong-Yu Jiang, Li-Yan He, Yi-Bing Huang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2012-06-01
Reeks:International Journal of Molecular Sciences
Onderwerpen:
anticancer peptides
<strong> </strong>helicity
hydrophobicity
mechanism of action
specificity
Online toegang:http://www.mdpi.com/1422-0067/13/6/6849
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