A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Abstract Background Alzheimer’s disease (AD) is the most common form of dementia. This neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting the cerebral cortex. AD has a substantial but heterogeneous genetic component, presenting both Mendelian and complex genet...

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Hlavní autoři: Jorge L. Del-Aguila, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Maria Victoria Fernandez, Laura Ibanez, Joseph Bradley, Fengxian Wang, Kristy Bergmann, Richard Davenport, John C. Morris, David M. Holtzman, Richard J. Perrin, Bruno A. Benitez, Joseph Dougherty, Carlos Cruchaga, Oscar Harari
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2019-08-01
Edice:Alzheimer’s Research & Therapy
Témata:
PSEN1
Single-nuclei RNA-seq
Alzheimer’s disease
Web-based brain molecular atlas
On-line přístup:http://link.springer.com/article/10.1186/s13195-019-0524-x
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