A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Abstract Background Alzheimer’s disease (AD) is the most common form of dementia. This neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting the cerebral cortex. AD has a substantial but heterogeneous genetic component, presenting both Mendelian and complex genet...

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Main Authors: Jorge L. Del-Aguila, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Maria Victoria Fernandez, Laura Ibanez, Joseph Bradley, Fengxian Wang, Kristy Bergmann, Richard Davenport, John C. Morris, David M. Holtzman, Richard J. Perrin, Bruno A. Benitez, Joseph Dougherty, Carlos Cruchaga, Oscar Harari
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-08-01
Serier:Alzheimer’s Research & Therapy
Fag:
PSEN1
Single-nuclei RNA-seq
Alzheimer’s disease
Web-based brain molecular atlas
Online adgang:http://link.springer.com/article/10.1186/s13195-019-0524-x
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