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Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.
Regulated intramembrane proteolysis of the amyloid precursor protein (APP) by the protease activities α-, β- and γ-secretase controls the generation of the neurotoxic amyloid β peptide. APLP2, the amyloid precursor-like protein 2, is a homolog of APP, which shows functional overlap with APP, but lac...
Wedi'i Gadw mewn:
Prif Awduron: | , , , |
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Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
Public Library of Science (PLoS)
2011-01-01
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Cyfres: | PLoS ONE |
Mynediad Ar-lein: | http://europepmc.org/articles/PMC3117885?pdf=render |
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