Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer

BACKGROUND: Amyloid precursor protein (APP), best known for its association with Alzheimer disease, has recently been implicated in breast cancer progression. However, the precise mechanism involved remains unclear. Here, we investigated the role of APP proteolytic cleavage in breast cancer function...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Tsang, Julia Y.S., Lee, Michelle A., Chan, Tsz-Hei, Li, Joshua, Ni, Yun-Bi, Shao, Yan, Chan, Siu-Ki, Cheungc, Sai-Yin, Lau, Kwok-Fai, Tse, Gary M.K.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306343/
https://ncbi.nlm.nih.gov/pubmed/30470613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.11.012
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