Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives

O-acetylserine sulfhydrylase (OASS) is the pyridoxal 5′-phosphate dependent enzyme that catalyses the formation of L-cysteine in bacteria and plants. Its inactivation is pursued as a strategy for the identification of novel antibiotics that, targeting dispensable proteins, holds a great promise for...

Full description

Saved in:
Bibliographic Details
Main Authors: Nina Franko, Konstantinos Grammatoglou, Barbara Campanini, Gabriele Costantino, Aigars Jirgensons, Andrea Mozzarelli
Format: Artigo
Language:Inglês
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Fluoroalanine
cysteine biosynthesis
enzyme inhibition
pyridoxal 5′-phosphate
Online Access:http://dx.doi.org/10.1080/14756366.2018.1504040
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items