Design of O-acetylserine sulfhydrylase inhibitors by mimicking Nature

The inhibition of cysteine biosynthesis in prokaryotes and protozoa has been proposed to be relevant for the development of antibiotics. Haemophilus influenzae O-acetylserine sulfhydrylase (OASS), catalyzing L-cysteine formation, is inhibited by the insertion of the C-terminal pentapeptide (MNLNI) o...

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Detalhes bibliográficos
Main Authors: Salsi, Enea, Bayden, Alexander S., Spyrakis, Francesca, Amadasi, Alessio, Campanini, Barbara, Bettati, Stefano, Dodatko, Tetyana, Cozzini, Pietro, Kellogg, Glen E., Cook, Paul F., Roderick, Steven L., Mozzarelli, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804909/
https://ncbi.nlm.nih.gov/pubmed/19928859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901325e
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