Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives

O-acetylserine sulfhydrylase (OASS) is the pyridoxal 5′-phosphate dependent enzyme that catalyses the formation of L-cysteine in bacteria and plants. Its inactivation is pursued as a strategy for the identification of novel antibiotics that, targeting dispensable proteins, holds a great promise for...

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Huvudupphovsmän: Nina Franko, Konstantinos Grammatoglou, Barbara Campanini, Gabriele Costantino, Aigars Jirgensons, Andrea Mozzarelli
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis Group 2018-01-01
Serie:Journal of Enzyme Inhibition and Medicinal Chemistry
Ämnen:
Fluoroalanine
cysteine biosynthesis
enzyme inhibition
pyridoxal 5′-phosphate
Länkar:http://dx.doi.org/10.1080/14756366.2018.1504040
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