Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology.

Microglial cells closely interact with senile plaques in Alzheimer's disease and acquire the morphological appearance of an activated phenotype. The significance of this microglial phenotype and the impact of microglia for disease progression have remained controversial. To uncover and characte...

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Bibliographic Details
Main Authors: Grietje Krabbe, Annett Halle, Vitali Matyash, Jan L Rinnenthal, Gina D Eom, Ulrike Bernhardt, Kelly R Miller, Stefan Prokop, Helmut Kettenmann, Frank L Heppner
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3620049?pdf=render
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