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Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

Microglial cells closely interact with senile plaques in Alzheimer’s disease and acquire the morphological appearance of an activated phenotype. The significance of this microglial phenotype and the impact of microglia for disease progression have remained controversial. To uncover and characterize...

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Détails bibliographiques
Auteurs principaux: Krabbe, Grietje, Halle, Annett, Matyash, Vitali, Rinnenthal, Jan L., Eom, Gina D., Bernhardt, Ulrike, Miller, Kelly R., Prokop, Stefan, Kettenmann, Helmut, Heppner, Frank L.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620049/
https://ncbi.nlm.nih.gov/pubmed/23577177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060921
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