Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK.

MK5 (MAPK-activated protein kinase 5) or PRAK (p38-regulated and -activated kinase) are alternative names for a serine/threonine protein kinase downstream to ERK3/4 and p38 MAPK. A previous gene targeting approach for MK5/PRAK (termed here MK5/PRAK-Δex8) revealed a seemingly tumor-suppressive role o...

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Bibliographic Details
Main Authors: Natalia Ronkina, Claus Johansen, Lisa Bohlmann, Juri Lafera, Manoj B Menon, Christopher Tiedje, Kathrin Laaß, Benjamin E Turk, Lars Iversen, Alexey Kotlyarov, Matthias Gaestel
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4546416?pdf=render
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