p38(MAPK)/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex

The nuclear exosome targeting complex (NEXT) directs a major 3′–5′ exonuclease, the RNA exosome, for degradation of nuclear noncoding (nc) RNAs. We identified the RNA-binding component of the NEXT complex, RBM7, as a substrate of p38(MAPK)/MK2-mediated phosphorylation at residue S136. As a result of...

Full description

Saved in:
Bibliographic Details
Published in:RNA
Main Authors: Tiedje, Christopher, Lubas, Michal, Tehrani, Mohammad, Menon, Manoj B., Ronkina, Natalia, Rousseau, Simon, Cohen, Philip, Kotlyarov, Alexey, Gaestel, Matthias
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2015
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338353/
https://ncbi.nlm.nih.gov/pubmed/25525152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.048090.114
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items