p38(MAPK)/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex

The nuclear exosome targeting complex (NEXT) directs a major 3′–5′ exonuclease, the RNA exosome, for degradation of nuclear noncoding (nc) RNAs. We identified the RNA-binding component of the NEXT complex, RBM7, as a substrate of p38(MAPK)/MK2-mediated phosphorylation at residue S136. As a result of...

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Gepubliceerd in:RNA
Hoofdauteurs: Tiedje, Christopher, Lubas, Michal, Tehrani, Mohammad, Menon, Manoj B., Ronkina, Natalia, Rousseau, Simon, Cohen, Philip, Kotlyarov, Alexey, Gaestel, Matthias
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2015
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338353/
https://ncbi.nlm.nih.gov/pubmed/25525152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.048090.114
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