The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU–Rich Element–Dependent Translation

TNF expression of macrophages is under stringent translational control that depends on the p38 MAPK/MK2 pathway and the AU–rich element (ARE) in the TNF mRNA. Here, we elucidate the molecular mechanism of phosphorylation-regulated translation of TNF. We demonstrate that translation of the TNF-precur...

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Bibliografiske detaljer
Main Authors: Tiedje, Christopher, Ronkina, Natalia, Tehrani, Mohammad, Dhamija, Sonam, Laass, Kathrin, Holtmann, Helmut, Kotlyarov, Alexey, Gaestel, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459988/
https://ncbi.nlm.nih.gov/pubmed/23028373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002977
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