The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU–Rich Element–Dependent Translation

TNF expression of macrophages is under stringent translational control that depends on the p38 MAPK/MK2 pathway and the AU–rich element (ARE) in the TNF mRNA. Here, we elucidate the molecular mechanism of phosphorylation-regulated translation of TNF. We demonstrate that translation of the TNF-precur...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tiedje, Christopher, Ronkina, Natalia, Tehrani, Mohammad, Dhamija, Sonam, Laass, Kathrin, Holtmann, Helmut, Kotlyarov, Alexey, Gaestel, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459988/
https://ncbi.nlm.nih.gov/pubmed/23028373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002977
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados