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Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
Abstract Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to α-ketoglutarate (α-KG) in the tricarboxylic acid (TCA) cycle. IDH mutation produces a neomorphic enzyme, which can lead to the abnormal accumulation of R-2-HG and promotes leukemogenesis. IDH mutation...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2019-10-01
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| Colecção: | Biomarker Research |
| Assuntos: | |
| Acesso em linha: | http://link.springer.com/article/10.1186/s40364-019-0173-z |
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