Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model

<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to evaluate the biodistribution and toxicity of amphotericin B (AmB) following multiple oral administrations of a novel tropically stable lipid-based formulation (iCo-010).</p> <p>Methods<...

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Hauptverfasser: Owen David, Zhao Jinying, Wasan Ellen K, Lin Molly, Gershkovich Pavel, Sivak Olena, Clement John G, Wasan Kishor M
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2011-08-01
Schriftenreihe:Lipids in Health and Disease
Schlagworte:
Lipid-based formulation
Intestinal absorption
Nephrotoxicity
Tissue distribution
Amphotericin B
Online Zugang:http://www.lipidworld.com/content/10/1/135
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