Safety, Tolerability, and Pharmacokinetics of a Novel Oral Amphotericin B Formulation (iCo-019) following Single-Dose Administration to Healthy Human Subjects: an Alternative Approach to Parenteral Amphotericin B Administration

This study evaluated the safety, tolerability, and pharmacokinetics of a novel oral amphotericin B (AmB) formulation (iCo-019) following single doses to healthy humans. The data from this study suggest that iCo-019 has a long circulation time and systemic exposure without the associated gastrointest...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Hnik, Peter, Wasan, Ellen K., Wasan, Kishor M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7508586/
https://ncbi.nlm.nih.gov/pubmed/32690643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01450-20
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