A Novel Tropically Stable Oral Amphotericin B Formulation (iCo-010) Exhibits Efficacy against Visceral Leishmaniasis in a Murine Model

PURPOSE: To develop an oral formulation of amphotericin B (AmB) that is stable at the temperatures of WHO Climatic Zones 3 and 4 (30–43°C) and to evaluate its efficacy in a murine model of visceral leishmaniasis (VL). METHODS: The stability testing of four novel oral lipid AmB formulations composed...

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Detalhes bibliográficos
Main Authors: Wasan, Ellen K., Gershkovich, Pavel, Zhao, Jinying, Zhu, Xiaohua, Werbovetz, Karl, Tidwell, Richard R., Clement, John G., Thornton, Sheila J., Wasan, Kishor M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998436/
https://ncbi.nlm.nih.gov/pubmed/21151883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000913
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