NKAP Regulates Senescence and Cell Death Pathways in Hematopoietic Progenitors

NKAP is a multi-functional nuclear protein that has been shown to be essential for hematopoiesis. Deletion of NKAP in hematopoietic stem cells (HSCs) was previously found to result in rapid lethality and hematopoietic failure. NKAP deficient cells also exhibited diminished proliferation and increase...

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Main Authors: Michael Jeremy Shapiro, Joshua Anderson, Michael Jonathan Lehrke, Meibo Chen, Molly Nelson Holte, Virginia Smith Shapiro
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-10-01
Colecção:Frontiers in Cell and Developmental Biology
Assuntos:
NKAP
hematopoiesis
cyclin dependent kinase inhibitor
senescence
apoptosis
Acesso em linha:https://www.frontiersin.org/article/10.3389/fcell.2019.00214/full
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