Interaction of Aβ42 with Membranes Triggers the Self-Assembly into Oligomers

The self-assembly of amyloid β (Aβ) proteins into oligomers is the major pathogenic event leading to Alzheimer’s disease (AD). Typical in vitro experiments require high protein concentrations, whereas the physiological concentration of Aβ is in the picomolar to l...

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Библиографические подробности
Главные авторы: Siddhartha Banerjee, Mohtadin Hashemi, Karen Zagorski, Yuri L. Lyubchenko
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2020-02-01
Серии:International Journal of Molecular Sciences
Предметы:
amyloid aggregation
supported lipid bilayers
time-lapse afm
alzheimer’s disease
molecular dynamics simulation
Online-ссылка:https://www.mdpi.com/1422-0067/21/3/1129
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