Internalization and Intoxication of Human Macrophages by the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent Upon Cellugyrin (Synaptogyrin-2)

The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing cell cycle arrest and apoptosis in lymphocytes and other cell types. Recently, we have demonstrated that human macrophages are resistant to Cdt-induced apoptosis but are susc...

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Main Authors: Kathleen Boesze-Battaglia, Anuradha Dhingra, Lisa M. Walker, Ali Zekavat, Bruce J. Shenker
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Assuntos:
cytolethal distending toxin
Aggregatibacter actinomycetemcomitans
macrophages
bacterial toxins
cellugyrin
lipid rafts
Acceso en liña:https://www.frontiersin.org/article/10.3389/fimmu.2020.01262/full
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